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Abstract: Poster Presentations |

SYNCHRONOUS LESIONS IN THE AIRWAYS OF AFRICAN AMERICAN MEN DIAGNOSED WITH LUNG CANCER FREE TO VIEW

Eric L. Flenaugh, MD*; Sadia Habib, MD; Nneka Okafor, MD; Nitin Puri, MD
Author and Funding Information

Morehouse School of Medicine, Atlanta, GA


Chest


Chest. 2005;128(4_MeetingAbstracts):322S. doi:10.1378/chest.128.4_MeetingAbstracts.322S-b
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Abstract

PURPOSE:  To determine the percentage of African American(AA) men with synchronous lesions present at the time lung cancer is diagnosed.

METHODS:  AA men with newly diagnosed lung cancer underwent autofluorescencebronchoscopy (AF) with the D-Light system (Storz, Tuttlingen, Germany). Synchronous lesions were detected, locations recorded, and biopsied. Findings were classified as metaplasia, dysplasia, carcinoma-in-situ(CIS), and carcinoma by independent pathologists.

RESULTS:  Twenty-three AA men with newly diagnosed lung cancer were enrolled.Thirty-five lesions were biopsied. Squamouscell carinoma was the histopathology of the primary lesion in 57% of patients, adenocarcinoma and small cell carcinoma in 26% and 17%,respectively. Of the synchronous lesions, 51% were metaplasia, 13% were dysplasia, 13% were CIS, 10% were synchronous carcinoma, and 13% were metastatic carcinoma. Significant changes in pre-procedure staging occurred in 13% of the patients following AF.

CONCLUSION:  1. Cancerization was present in 87% of AA men at the time of the initial diagnosis with primary lung cancer.2. AF helped identify patients with lesions that carry a high risk of developing into second primary lung cancers. 3. AF improved the accuracy of staging and identified synchronous lesions in 13% of the patients studied. This resulted in a change of the tumor staging and treatment options.

CLINICAL IMPLICATIONS:  In select patient populations, AF could prove to be an essential tool for improving healthcare disparities.

DISCLOSURE:  Eric Flenaugh, Grant monies (from sources other than industry) The Georgia Cancer Center of Excellence: NIH #5 P60 MD 47-1.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


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