To determine the percentage of African American(AA) men with synchronous lesions present at the time lung cancer is diagnosed.
AA men with newly diagnosed lung cancer underwent autofluorescencebronchoscopy (AF) with the D-Light system (Storz, Tuttlingen, Germany). Synchronous lesions were detected, locations recorded, and biopsied. Findings were classified as metaplasia, dysplasia, carcinoma-in-situ(CIS), and carcinoma by independent pathologists.
Twenty-three AA men with newly diagnosed lung cancer were enrolled.Thirty-five lesions were biopsied. Squamouscell carinoma was the histopathology of the primary lesion in 57% of patients, adenocarcinoma and small cell carcinoma in 26% and 17%,respectively. Of the synchronous lesions, 51% were metaplasia, 13% were dysplasia, 13% were CIS, 10% were synchronous carcinoma, and 13% were metastatic carcinoma. Significant changes in pre-procedure staging occurred in 13% of the patients following AF.
1. Cancerization was present in 87% of AA men at the time of the initial diagnosis with primary lung cancer.2. AF helped identify patients with lesions that carry a high risk of developing into second primary lung cancers. 3. AF improved the accuracy of staging and identified synchronous lesions in 13% of the patients studied. This resulted in a change of the tumor staging and treatment options.
In select patient populations, AF could prove to be an essential tool for improving healthcare disparities.
Eric Flenaugh, Grant monies (from sources other than industry) The Georgia Cancer Center of Excellence: NIH #5 P60 MD 47-1.