To determine the association of reduced carbon monoxide diffusing capacity (DLCO) with moderate or severe left ventricular diastolic dysfunction (LVDD) in obese persons.
We investigated in 105 obese persons, mean age 45 years, the association of DLCO with LVDD. An abnormal DLCO was <80%. LVDD was investigated by Doppler and by tissue Doppler echocardiography. The Doppler echocardiographic data were analyzed blindly without knowledge of the clinical characteristics or whether the DLCO was normal or abnormal.
An abnormal DLCO was present in 62 of 105 persons (59%). Moderate or severe LVDD was present in 35 of 105 persons 33%).Moderate or severe LVDD was present in 25 of 62 persons (40%) with an abnormal DLCO and in 10 of 43 persons (23%) with a normal DLCO (p<0.05).
Obese persons with a decreased DLCO have an increased prevalence of moderate or severe LVDD.
Obese persons with a decreased DLCO have an increased prevalence of moderate or severe LVDD, which predisposes them to develop diastolic heart failure.
Gautham Ravipati, None.