Gastro Esophageal Reflux (GER) is well described in patients with Asthma and Chronic Obstructive Pulmonary Disease (COPD). The purpose of this study was to determine prevalence of GER symptoms among patients with Chronic Respiratory failure (CRF) due to COPD.
The study included two groups of patients: Group I: 70 patients with COPD and CRF and Group II: 50 patients with COPD and Acute Respiratory Failure (ARF). All patients were treated for exacerbation at Institute for pulmonary diseases in Belgrade. Pulmonary function tests (PFT) and blood gas analysis (BGA) were performed in all patients. After collecting basic demographic and habit information, all patients filled out Mayo Clinic Gastro Esophageal Reflux Questionnaire.
In group I was 48 male and 22 female mean age 61±5 years. PFT results were: FEV1 36±10%, FEV1/FVC 42±8%. BGA analysis: PO2 6.8±10 Kpa, PCO2 8.1 ±4Kpa, Sat 85±8%. In group II was 35 male and 15 female, mean age 54 ± 8 years. PFT results were FEV1 49±3.2%, FEV1/FVC 48±10%. BGA analysis were: PO2 7.1±5.5Kpa, PCO2 6.9±2Kpa, Sat 89±11%. GER symptoms in group I vs. group II were: acid regurgitation (68% vs. 55%), dysphagia (30% vs.19%), heartburn (81% vs.70%), chronic cough (71% vs. 67%) and hoarseness (15% vs. 8%). Both groups have significant GER symptoms, but difference did not reach statistical significance (p>0.05). Heartburn and acid regurgitation occurs daily and it was described as hard or very hard. Average duration of heartburn and acid regurgitation was 10±4 years. All patients occasionally take anti reflux drugs mostly during exacerbation of disease.
GER symptoms are significantly present in patients with CRF due to COPD. There was a trend toward higher prevalence of GER symptoms among patients with CRF comparing to patients with ARF, but the difference did not reach statistical significance.
Patients with respiratory failure due to COPD (both acute and chronic) require further medical investigation and appropriate therapy with anti reflux drugs.
Snezana Raljevic, None.