About one-third of women with asthma (A) have an increase in asthma symptoms during in menstrual period. Patients affected by premenstrual asthma (PA) in comparison to asthmatic women without premenstrual asthma (WPA), generally have more sever symptoms and more frequently hospitalization. Hormonal fluctuations and changes during the menstrual cycle may be responsible for PA occurring. GSTT1, GSTM1 genes take part in detoxification and excretion of xenobiotics from organism, and also in metabolism of prostaglandins, leukotreine and sexual hormones. Allergy also is a major risk factor for asthma. To evaluate the role of GSTT1 and GSTM1 genotypes and allergy in susceptibility to PA, we conducted the given study.
We survey 74 asthmatic women, 9 (12.16%) with PA, average age 44.95±1.50 years and 65 (87.84%) WPA, average age 44.47±1.22 years. All subjects were interviewed using a special questionnaire, which allowed taking into account presence or absence of symptoms of asthma related to menstrual cycle and allergy. Allergy is also assessed by skin prick test. GSTT1 and GSTM1 genotypes were identified by multiplex polymerase chain reaction.
We found that the frequency of GSTT1 functional allele in women with PA was 100% and in asthmatic women WPA was 68.96% (p=0.0001).The frequency of allergy in patients WPA was 83.07% and in women with PA was 44.45% (χ2 =4.37, P=0.027).
We concluded that:1) The patients with PA have a significantly higher frequency of GSTT1 functional genotype as compared to those WPA.2) The frequency of allergy in patients WPA is significantly higher, then in cases with PA.
The diagnosis of premenstrual asthma as one form of sever asthma in related to GSTM1 and GSTT1 genotypes in women.
Natalia Gorovenko, None.