In bronchial asthma, airway wall remodeling may result in reduced airway distensibility. In this study, we assessed in asthmatic patients both the baseline airway caliber and distensibility by means of High Resolution Computed Tomography (HRCT).
We studied 7 patients (2 M, age range: 36-69 yrs) affected by chronic asthma (FEV1 range: 30-87 % of predicted; FEV1/VC range: 48-75 % of predicted) in stable clinical conditions and 6 healthy subjects (3 M, age range: 29-50 yrs), as a control group. In all subjects, HRCT scanning, obtained at suspended end-espiratory volume, was performed at rest and during ventilation with 6 and 12 cmH2O by nCPAP, both at baseline and after the inhalation of 200 mcg oxitropium bromide MDI.. External and lumen diameter (mm) of the right apical upper lobe bronchus were measured in all HRCT scans.
Results (means±SD) are listed in the table.
Our results showed that in asthmatic patients the airway distensibility, assessed by HRCT, could differ as compared to that of healthy controls.
HRCT can provide useful information on airway distensibility.
Antonio Castagnaro, None.Asthmatics PatientsBaselineAfter OxitropiumAt rest6 cmH2O12 cmH2OAt rest6 cmH2O12 cmH2Oexternal Ø (mm)6.2±0.96.3±0.96.7±0.8*7.3±16.9±0.77.1±0.9lumen Ø (mm)3.3±0.73.5±0.63.8±0.6*4.4±0.63.8±0.44±0.4Healthy Controlsexternal Ø (mm)7.3±1.87.9±1.77.8±28±1.68±1.89±1.7lumen Ø (mm)4.0±1.64.8±1.6*4.7±1.7*5±1.55±1.4*6±1.6**
p< 0.05 vs at rest