OSA is a relatively common condition with a prevalence of 5%. Significant reduction in QOL is the major complication OSA.Continuous positive airway pressure (CPAP) titrated to eliminate Apnea and Hypoapnea significantly improve quality of life. Previous study indicates there is no correlation between QOL and severity of sleep apnea. There are various physical and polysomnographic finding that associated with the decrease in health related QOL in this cohort study. The purpose of this study is to evaluate the impact of polysomnographic features and physical characteristics to health related QOL in a patient with OSA.
The Study was conducted in sleep laboratory of Kings County medical center, Brooklyn, New York. We studied 34 adult (22 male and 12 female) patients with mean age of 45 (19-72), a body mass index (BMI) of 41.99 and diagnosis of OSA (apnea-hypoapnea index more than 5). Patients with major medical and psychiatric illness were excluded. Baseline physical and polysomnographic characteristics were obtained. The health related QOL was assessed by administering medical outcomes short-form ( MOS SF-36), a 36-item questionnaire that summarizes health related QOL using eight subscales and two summary scores. The results were analyzed using Pearson correlation statistics.
The was significant negative correlation between BMI and SF-36 physical score ( p<0.001). Subclass analysis also showed significant correlation between BMI and all components. There was also positive correlation between sleep efficiency and physical functioning and mental health. It is of note that there was no significant correlation between apnea-hypoanea index (AHI), arousal index, nocturnal oxygen desaturation (NOD) and the SF-36 physical and mental health scores.
AHI factor that define OSA may not determine the severity of disease outcome with respect to health related QOL.The study showed the significant impact of obesity on QOL in patients with OSA.
weight reduction measures should aggressively be incorporated in management of OSA to improve their QOL. The positive association in sleep efficiency and QOL may indicate possible mechanism of improvement of QOL with CPAP.
Asegid Kebede, None.