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Abstract: Slide Presentations |

COMBINATION THERAPY OF TIOTROPIUM PLUS SALMETEROL (T+S) SUPERIOR TO SINGLE AGENT THERAPY (TIO OR SALM) IN TERMS OF DYSPNEA IMPROVEMENT IN COPD FREE TO VIEW

JA Van Noord, MD*; J-L Aumann, MD; E Janssens, MD; JJ Smeets; A Mueller; PJG Cornelissen, PhD
Author and Funding Information

Atrium Medical Center, Heerlen, Netherlands


Chest


Chest. 2005;128(4_MeetingAbstracts):177S-b-178S. doi:10.1378/chest.128.4_MeetingAbstracts.177S-b
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Abstract

PURPOSE:  Guidelines recommend combination therapy of long-acting bronchodilators in moderate to severe COPD.

METHODS:  Baseline and Transition Dyspnea Indices (BDI and TDI) were assessed at the end of 6-week treatment periods in a 4-way, double-blind, crossover study of Tio 18 mcg (qd), Salm 50 mcg (bid), T (qd) + S (qd) or T (qd) + S (bid). In addition, bronchodilator-mediated symptom benefit was evaluated by the need for reliever medication (puffs of salbutamol during last 3 weeks of each period).

RESULTS:  Mean screening FEV1 of the study population (N=97; 77 m/20 f, aged 65 yrs) was 1.09 L (39 % pred). The BDI was 6.9. A TDI (focal score) ≥ 1 unit is considered clinically relevant.

CONCLUSION:  This is the first study with crossover design using BDI/TDI to assess dyspnea. Combination therapy was superior to single agent therapies in perceived dyspnea; no difference was found between once- or twice-daily Salm add-on therapy to Tio. Symptom benefit of combination regimens over the single agents was also reflected in less need for reliever medication.

CLINICAL IMPLICATIONS:  In conclusion, combination therapy of T+S provided superior and clinically relevant improvement in dyspnea and less need for reliever medication compared to single agent therapies in moderate to severe COPD.

DISCLOSURE:  JA Van Noord, Grant monies (from industry related sources) First three authors received honorarium to conduct clinical research.

Tuesday, November 1, 2005

12:30 AM - 2:00 PM


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