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Abstract: Slide Presentations |

CLINICAL EFFICACY OF LINEZOLID, CLARITHROMYCIN AND CAPREOMYCIN IN THE TREATMENT OF MULTI-DRUG RESISTANT PULMONARY TUBERCULOSIS FREE TO VIEW

Sudhir K. Agarwal, MD*
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Institute of Medical Sciences, Banaras Hindu University, Varanasi, India


Chest


Chest. 2005;128(4_MeetingAbstracts):176S. doi:10.1378/chest.128.4_MeetingAbstracts.176S
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Abstract

PURPOSE:  Objective of the study was to see the clinical efficacy of a combination therapy with linezolid (L), azithromycin (AZ), capreomycin (CPM) and other second-line anti-tuberculosis drugs in the treatment of multi-drug resistant pulmonary tuberculosis (MDR-TB).

METHODS:  Ninety-one patients with MDR-TB were assigned to a study group (46 cases), treated with L, AZ, CPM, pyrazinamide (Z), ethambutol (E) and ethionamide( Et); or a control group ( 45 cases), treated with streptomycin (S), Z, E and Et. The course of treatment was 18 months. Linezolid was given for 6 months and aminoglycosides (capreomycin/streptomycin) for 10 weeks.

RESULTS:  42 cases in the study group and 41 in the control group completed the treatment. The sputum negative conversion in the study group (81%) was significantly higher than in the control group (55%). The radiological improvement rate was 46% in the study group, significantly higher than that in the control group (27%) (P<0.01). The closure rate of the lung cavities in the study group (65%) was higher than in the control group (44%) (P<0.05). No significant difference was found in the side-effects between the two groups.

CONCLUSION:  The regimen including linezolid, clarithromycin, capreomycin and other second-line anti-TB drugs was effective and safe for the patients with MDR-TB.

CLINICAL IMPLICATIONS:  Linezolid, clarithromycin and capreomycin combination may be used along with other anti-tuberculosis drugs for the management of MDR TB.

DISCLOSURE:  Sudhir Agarwal, None.

Tuesday, November 1, 2005

10:30 AM - 12:00 PM


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