Routine brain MRI as a staging work-up of non-small cell lung cancer remains controversial, although adenocarcinoma of the lung has a high frequency of brain metastasis. To estimate the incidence of brain metastasis in patients with neurologically asymptomatic adenocarcinoma of the lung and to determine the usefulness of routine brain MRI, this study was designed prospectively.
From May 1999 to April 2004, we performed routine brain MRI in all patients with newly diagnosed adenocarcinoma of the lung in Samsung Medical Center. The patients with any neurologic signs and/or symptoms were excluded. Brain MRI consisted of pre- and post-contrast image. The radiographically positive findings were acceptable only when two experienced neuroradiologists readed the same findings independently.
Total 782 (median age 61 years, M:F=1.52:1) patients were enrolled. Overall positive rate on brain MR was 23.0%(180/782). The incidence of asymptomatic brain metastasis was presented to the table.
Brain MRI could be helpful for the diagnosis of occult brain metastasis in patients with adenocarcinoma of the lung.
Lung cancer, brain metastasis.
Eun Kang, None.