Bronchodilator-responsiveness in COPD patients (defined as a 12% and ≥200 ml improvement in FEV1) has rarely been studied as a prognostic factor in patient outcomes. In order to correlate bronchodilator-responsiveness and frequency of hospitalizations in COPD patients, we retrospectively reviewed our experience with two groups of patients with COPD.
We retrospectively reviewed the pulmonary function studies of 166 patients with the diagnosis of COPD between 2000 and 2003 and divided them into two groups, based on the above-outlined criteria: Group I: Non-Responders (NR): 123 patients, and Group 2: Responders (R): 43 patients. We then contacted all patients by phone and reviewed their hospital records about the frequency of COPD-related admissions during 2004.
There were 33 hospitalizations among 123 patients in NR Group and only 3 hospitalizations among 43 patients in R Group. Using Fischer Exact Test to compare the two groups, we found a statistically significant difference (P value: 0.0052, odds ratio: 0.218, and 95% confidence interval: 0.06-0.71).
COPD patients who are non-responders (NR) to bronchodilators have a more complicated course than responders (R) as evidenced by a significantly greater frequency of hospitalizations due to acute exacerbations.
Bronchodilator-responsiveness in COPD patients predicts better prognosis.
M.M. Ismail, None.ClassificationRespondersNon-RespondersNo. of patients43123No. of hospitalizations333