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BRONCHODILATOR-RESPONSIVENESS AS A PROGNOSTIC FACTOR IN COPD FREE TO VIEW

M.M. Ismail, MD*; M. Moammar, MD; H. Aziz, MD; M. Shubair, MD; V. DeBari, PhD; M.A. Khan, MD
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St. Joseph’s Regional Medical Center, Paterson, NJ


Chest


Chest. 2005;128(4_MeetingAbstracts):158S-b-159S. doi:10.1378/chest.128.4_MeetingAbstracts.158S-b
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Abstract

PURPOSE:  Bronchodilator-responsiveness in COPD patients (defined as a 12% and ≥200 ml improvement in FEV1) has rarely been studied as a prognostic factor in patient outcomes. In order to correlate bronchodilator-responsiveness and frequency of hospitalizations in COPD patients, we retrospectively reviewed our experience with two groups of patients with COPD.

METHODS:  We retrospectively reviewed the pulmonary function studies of 166 patients with the diagnosis of COPD between 2000 and 2003 and divided them into two groups, based on the above-outlined criteria: Group I: Non-Responders (NR): 123 patients, and Group 2: Responders (R): 43 patients. We then contacted all patients by phone and reviewed their hospital records about the frequency of COPD-related admissions during 2004.

RESULTS:  There were 33 hospitalizations among 123 patients in NR Group and only 3 hospitalizations among 43 patients in R Group. Using Fischer Exact Test to compare the two groups, we found a statistically significant difference (P value: 0.0052, odds ratio: 0.218, and 95% confidence interval: 0.06-0.71).

CONCLUSION:  COPD patients who are non-responders (NR) to bronchodilators have a more complicated course than responders (R) as evidenced by a significantly greater frequency of hospitalizations due to acute exacerbations.

CLINICAL IMPLICATIONS:  Bronchodilator-responsiveness in COPD patients predicts better prognosis.

DISCLOSURE:  M.M. Ismail, None.ClassificationRespondersNon-RespondersNo. of patients43123No. of hospitalizations333

Monday, October 31, 2005

2:30 PM - 4:00 PM


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