0
Correspondence |

Regulatory T Cells, Allergic Diseases, and Cancer FREE TO VIEW

Luca Mascitelli, MD; Francesca Pezzetta, MD
Author and Funding Information

Affiliations: Sanitary Service, Comando Brigata Alpina “Julia”, Udine, Italy,  Ospedale di San Vito al Tagliamento, San Vito al Tagliamento, Italy

Correspondence to: Luca Mascitelli, MD, Comando Brigata Alpina Julia, Sanitary Service, Via S Agostino, 8, Udine 33100, Italy; e-mail: lumasci@libero.it


Chest. 2008;133(3):832. doi:10.1378/chest.07-2313
Text Size: A A A
Published online

To the Editor:

Larchè in his excellent review in a recent issue of CHEST (September 2007)1 highlighted the potential defective function of regulatory T cells (Tregs) in patients with allergic diseases, and suggested that the induction of Treg development might be useful in this field. However, he did not discuss the effects of Tregs on immunopathology in cancer patients.

Tregs play an essential role in immune homeostasis and protection against autoimmunity, but also exert a detrimental action in the generation of host-vs-tumor immunity via the suppression of tumor-specific effector T-cell responses and the development of immune tolerance to neoplastic cells.2Indeed, many of the mechanisms that impede antitumor immunity result in the development of Tregs.3Animal models for cancer have shown that Treg depletion improves antitumor immunity and the success of immunotherapy4; the hypothesis that a reduction of Treg function in cancer patients could be therapeutic is currently investigated.5 Therefore, the therapeutic manipulation of Tregs should always consider the double-edged sword of this action.

The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Larché, M (2007) Regulatory T cells in allergy and asthma.Chest132,1007-1014
 
Yakirevich, E, Resnick, MB Regulatory T lymphocytes: pivotal components of the host antitumor response.J Clin Oncol2007;25,2506-2508
 
Curiel, TJ Tregs and rethinking cancer immunotherapy.J Clin Invest2007;117,1167-1174
 
Shimizu, J, Yamazaki, S, Sakaguchi, S Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity.J Immunol1999;163,5211-5218
 
Barnett, B, Kryczek, I, Cheng, P, et al Regulatory T cells in ovarian cancer: biology and therapeutic potential.Am J Reprod Immunol2005;54,369-377
 

Figures

Tables

References

Larché, M (2007) Regulatory T cells in allergy and asthma.Chest132,1007-1014
 
Yakirevich, E, Resnick, MB Regulatory T lymphocytes: pivotal components of the host antitumor response.J Clin Oncol2007;25,2506-2508
 
Curiel, TJ Tregs and rethinking cancer immunotherapy.J Clin Invest2007;117,1167-1174
 
Shimizu, J, Yamazaki, S, Sakaguchi, S Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity.J Immunol1999;163,5211-5218
 
Barnett, B, Kryczek, I, Cheng, P, et al Regulatory T cells in ovarian cancer: biology and therapeutic potential.Am J Reprod Immunol2005;54,369-377
 
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543