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Original Research: INTERVENTIONAL PULMONOLOGY |

Photodynamic Therapy for Airway Stenosis in Rabbit Models*

Yoshinori Nakagishi, MD; Yuji Morimoto, MD, PhD; Masanori Fujita, MD, PhD; Noriko Morimoto, MD, PhD; Yuichi Ozeki, MD, PhD; Tadaaki Maehara, MD, PhD; Makoto Kikuchi, PhD
Author and Funding Information

*From the Departments of Medical Engineering (Drs. Nakagishi and Kikuchi), Surgery (Drs. Fujita, Ozeki, and Maehara), and Integrative Physiology and Bio-Nano Medicine (Dr. Y. Morimoto), National Defense Medical College, Tokorozawa, Saitama; and Department of Otolaryngology (Dr. N. Morimoto), National Center for Child Health and Development, Setagaya, Tokyo, Japan.

Correspondence to: Yoshinori Nakagishi, MD, Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan; e-mail: grd1708@ndmc.ac.jp



Chest. 2008;133(1):123-130. doi:10.1378/chest.07-1410
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Background: Acquired airway stenosis in childhood is resistant to conventional treatment. We examined whether endoscope-assisted photodynamic therapy (PDT) is effective for airway stenosis in animal models of which the pathophysiologic progressions are similar to those of clinical cases showing rapid deterioration.

Methods: Tracheal mucosa-scraped rabbits were administered IV porfimer sodium (Photofrin; Wyeth K.K., Tokyo, Japan) [2 mg/kg], and the tracheal lesions were irradiated with 630 nm of light emitted from a cylindrical diffuser tip via a transtracheal approach.

Results: Rabbits without PDT (untreated animals) showed dense granulation tissue in the scraped lesion, resulting in airway stenosis complicated with respiratory stridor. PDT ameliorated the degree of airway stenosis (p = 0.008) and reduced respiratory stridor; rabbits that received PDT showed patchy granulation tissue that was only 20 to 30% of the volume of that seen in the untreated animals. Survival time of rabbits that received PDT was significantly prolonged compared with that of untreated animals (p = 0.03).

Conclusions: PDT was effective for airway stenosis in rabbit models. This suggests that PDT has the potential as a new therapeutic method for airway stenosis originating from granulation tissue.

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