It took a proactive approach by the board of The Institute to put the topic on a different trajectory. Convening a diverse group of leaders to discuss the problem was a first step. Formalizing and funding their ongoing network was the more important one. Seeding promising new approaches across a spectrum from bench science to peer education became the hallmark of the initiative. Mapping, monitoring, and sharing data and outcomes through the Chicago Asthma Atlas, the Chicago Asthma Surveillance Initiative, and the Chicago Asthma Consortium and its annual data workshop resulted in improved understanding of what works, who is effective, and where additional interventions are needed. After more than a decade of encouragement, several of these programs have become self-sustaining, while the principal investigators have continued to attract larger grants from government, foundation, and corporate sources. Problem-based learning and patient empowerment were tested and proven as cost-effective techniques to achieve better asthma outcomes. Mobile C.A.R.E. has demonstrated impressive results through its community-based approach. The value of collaboration also has been recognized. The Chicago Asthma Consortium model now has been replicated in dozens of communities across the nation. To maintain and strengthen this national asthma network, the CHEST Foundation convenes them annually. (It also has been adapted by The Otho S. A. Sprague Memorial Institute to address other health issues including childhood obesity through its role as the cofounder of the Consortium to Lower Obesity in Chicago Children, which has emerged as a national model.) While this is encouraging, networking is not enough. It takes sustained focus and increased funding if health outcomes are to be improved and disparities decreased.