0
Editorials |

Airway Inflammation in AsthmaThymic Stromal Lymphopoietin in Asthma: Multiple Roles for Thymic Stromal Lymphopoietin

Dave Singh, MD
Author and Funding Information

University Of Manchester, Medicines Evaluation Unit, University Hospital Of South Manchester.

Correspondence to: Dave Singh, MD, University of Manchester, Medicines Evaluation Unit, Langley Building, University Hospital of South Manchester, Wythenshawe, Manchester, M23 9QZ, England; e-mail: dsingh@meu.org.uk

Financial/nonfinancial disclosures: The author has reported to CHEST the following conflicts of interest: Dr Singh has received lecture fees, research grants, consultancy fees, and support for conference attendance from various pharmaceutical companies, including AstraZeneca, GlaxoSmithKline, Chiesi Ltd, Boehringer Ingelheim GmbH, Hoffman-La Roche Inc, Novartis AG, Cipla, Forest Laboratories Inc, Almirall, Nycomed, and Merck.


Financial/nonfinancial disclosures: The author has reported to CHEST the following conflicts of interest: Dr Singh has received lecture fees, research grants, consultancy fees, and support for conference attendance from various pharmaceutical companies, including AstraZeneca, GlaxoSmithKline, Chiesi Ltd, Boehringer Ingelheim GmbH, Hoffman-La Roche Inc, Novartis AG, Cipla, Forest Laboratories Inc, Almirall, Nycomed, and Merck.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(1):11-13. doi:10.1378/chest.11-3162
Text Size: A A A
Published online

Extract

Many patients with asthma have persistent symptoms associated with chronic inflammation despite treatment with corticosteroids. Novel approaches to the treatment of such patients include the administration of therapies targeting specific cytokines believed to be involved in persistent airway inflammation.1,2 One such candidate is thymic stromal lymphopoietin (TSLP). This cytokine upregulates the expression of OX40 ligand (OX40L) on dendritic cells, which interacts with OX40 on T cells to promote the production of TH2 cytokines such as IL-4, IL-5, and IL-13.3 TSLP has other proinflammatory effects, including the upregulation of cytokine and chemokine production from dendritic cells and mast cells.3 Animal models have implicated TSLP in allergic lung inflammation.3,4

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543