From the Department of Pulmonary Diseases and Department of Paediatrics (Dr Quanjer), Erasmus Medical Centre, Erasmus University; and MRC Centre of Epidemiology for Child Health (Dr Cole), UCL Institute of Child Health.
Correspondence to: Philip H. Quanjer, MD, PhD, Kervel 19, 7443 GT, Nijverdal, The Netherlands; e-mail: firstname.lastname@example.org
Financial/nonfinancial disclosure: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).
© 2012 American College of Chest Physicians
An abnormally low FEV1/FVC ratio is universally accepted as indicative of obstructive lung disease. Clearly, the choice of cutoff to define abnormality is important. The GOLD (Global Initiative for Chronic Obstructive Lung Disease) group set the lower limit of normal (LLN) at 0.7 irrespective of age, defining GOLD COPD stage I as FEV1/FVC below 0.7 and FEV1 above 80% predicted.1 In a recent issue of CHEST (January 2012), Mannino and Diaz-Guzman2 argue that patients in GOLD stage I are at increased risk of premature death from respiratory causes.
As shown in many publications, the 0.7 cutoff is too simplistic. After age 45, the LLN based on the fifth centile of the FEV1/FVC ratio falls progressively below 0.7, meaning that the 0.7 cutoff identifies many older patients above the LLN as false positives. Several studies have tried to validate GOLD stage I for identifying obstructive lung disease:
In asymptomatic subjects, it was neither associated with premature death3,4 nor with an abnormal decline in FEV1, respiratory care use, or quality of life compared with a reference group.5
It was not associated with premature death or respiratory symptoms.6
The adjusted hazard ratio for premature death was not significant.7
Now, Mannino and Diaz-Guzman2 state that subjects in GOLD stage I who are above the LLN are at increased risk of premature death from respiratory causes. They fail to present adjusted hazard ratios for respiratory death. Hence, their conclusion lacks evidence; it also contradicts a previous study where the same analysis was done on the same data.6
Thus, there is no evidence to support the use of GOLD stage I. Conversely, there is considerable evidence in favor of the LLN:
Only GOLD stage I with FEV1/FVC below the LLN was associated with increased risk of death.6,7
The use of the LLN for both FEV1/FVC and FEV1, rather than a fixed ratio and 80% predicted, identified persons with an increased risk of death and prevalence of respiratory symptoms.8
“After correction for potential confounders, only severe COPD as defined by the BTS [British Thoracic Society] criteria was still associated with mortality.”9
We conclude that GOLD stage I is not associated with respiratory disease or death from respiratory causes unless FEV1/FVC is below the LLN. Incorrectly labeling subjects as having COPD by the GOLD criteria has detrimental consequences for the individual and family: It incurs high costs for society, and it hampers research into the causes of COPD and its treatment. The mystery is why the GOLD group continues to encourage its use.
Become a CHEST member and receive a FREE subscription as a benefit of membership.
Individuals can purchase this article on ScienceDirect.
Individuals can purchase a subscription to the journal.
Individuals can purchase a subscription to the journal or buy individual articles.
Learn more about membership or Purchase a Full Subscription.
Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 4
Customize your page view by dragging & repositioning the boxes below.
Enter your username and email address. We'll send you a reminder to the email address on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.