To look at this question further, we have also conducted a similar prospective analysis in our own institution of the diagnostic accuracy of EBUS-TBNA. This involved one operator only who was previously trained in the technique elsewhere. One hundred sixty consecutive EBUS-TBNA procedures were performed over an 18-month period for a similar unselected cohort of patients with mediastinal or hilar lymph nodes in a UK center receiving tertiary referrals for EBUS-TBNA. Patients were included with lymph nodes >10 mm short axis diameter on CT scan. Two hundred ninety-two nodes were sampled in 160 patients (84 with lung cancer, eight with extrapulmonary carcinoma, three with lymphoma, 37 with positively diagnosed benign pathologies, and a further 28 with reactive nodes stable or regressing on prolonged follow-up). Diagnostic accuracy (in percentages) and number of nodes sampled are as following, in order of consecutive octiles from 1 to 20 until 140 to 160: 85, 85, 90, 90, 90, 95, 90, 100 and 2, 2, 2.2, 1.5, 1.5, 1.6, 1.8, 2, respectively.