Inactivity, at least in the first days to weeks, appears to be the norm after having a stroke or being managed in the ICU. Inactivity may simply be a consequence of the intensive monitoring, investigation, and treatment protocols, combined with high dependence on others to move. Or bed rest may be consciously prescribed by the treating team. There is no doubt, however, that the potential harms of bed rest, and the benefits of activity, both outlined by Schweickert and Kress,1 should provide incentive for us to minimize bed rest as much, and as soon, as possible. In the stroke population and perhaps more broadly, further incentive for promoting early physical activity comes from experimental studies demonstrating the experience-dependent nature of neuroplasticity2 and the role physical activity plays in helping drive recovery of the damaged brain. In short, it is biologically plausible that EM may be helpful for acute patients, if it is not harmful.