Over the last 20 years, there has been a greater appreciation of the clinical importance and complexity of myocardial repolarization. The landmark Cardiac Arrhythmia Suppression Trial showed that drugs that affect myocardial depolarization actually were associated with increased mortality due to proarrhythmic effects, and over the past decade scientists and pharmaceutical companies have focused on developing antiarrhythmic drugs that delay myocardial repolarization. In Myocardial Repolarization: From Gene to Bedside, Oto and Breithardt provide a timely and comprehensive review of both the basic electrophysiology and the clinical aspects of myocardial repolarization. The editors have gathered an internationally renowned group of more than 50 contributors who discuss specific aspects of repolarization in 25 succinct chapters, each approximately 10 to 15 pages in length. This format allows one or two chapters to be read easily in an evening. In general, the book is well-illustrated, and the editors have done an excellent job in providing chapters that have a uniform structure throughout with minimal subject overlap.