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Interstitial Pneumonia Associated With Bullous PemphigoidInterstitial Pneumonia in Bullous Pemphigoid

Daisuke Yoshioka, MD; Hiroshi Ishii, MD, PhD; Tomohisa Uchida, MD; Sakuhei Fujiwara, MD; Kenji Umeki, MD; Noriho Sakamoto, MD; Jun-ichi Kadota, MD
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From the Department of Internal Medicine II (Drs Yoshioka, Ishii, Umeki, and Kadota), the Department of Molecular Pathology (Dr Uchida), and the Department of Dermatology (Dr Fujiwara), Oita University Faculty of Medicine, Oita; and The Second Department of Internal Medicine (Dr Sakamoto), Nagasaki University Hospital, Nagasaki, Japan.

Correspondence to: Hiroshi Ishii, MD, PhD, Internal Medicine II, Oita University Faculty of Medicine, 1-1 Idaigaoka, Yufu, Oita, Japan 879-5593; e-mail: hishii@oita-u.ac.jp


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2012 American College of Chest Physicians


Chest. 2012;141(3):795-797. doi:10.1378/chest.11-1241
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Bullous pemphigoid, the most common autoimmune blistering disease, is characterized by an autoimmune response to a component of hemidesmosomes within the dermal-epidermal junction. Immunofluorescence examination of skin biopsies demonstrates linear deposition of IgG and C3 in the basement membrane zone. A 73-year-old woman was admitted to our institution because of interstitial lung disease with persistent dry cough, dyspnea on exertion, and bullous eruptions on the skin of her trunk and extremities. Chest CT scan, BAL fluid, and transbronchial lung biopsy findings indicated a likely nonspecific interstitial pneumonia pattern. Direct immunofluorescence showed linear deposition of IgG and C3 along the basement membranes of the lung and skin specimens. Lung disorders associated with bullous pemphigoid are extremely rare, and, to our knowledge, this is the first report of an immunologically confirmed case of interstitial pneumonia.

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