0
Original Research: PULMONARY VASCULAR DISEASE |

Obesity and Right Ventricular Structure and FunctionObesity and the Right Ventricle: The MESA-Right Ventricle Study

Harjit Chahal, MD, MPH; Robyn L. McClelland, PhD; Harikrishna Tandri, MD; Aditya Jain, MD, MPH; Evrim B. Turkbey, MD; W. Gregory Hundley, MD, MHS; R. Graham Barr, MD, DrPH; Jorge Kizer, MD; João A. C. Lima, MD; David A. Bluemke, MD, PhD; Steven M. Kawut, MD, FCCP
Author and Funding Information

From the Department of Radiology (Drs Chahal and Jain) and the Department of Medicine (Drs Tandri and Lima), Johns Hopkins University School of Medicine, Baltimore, MD; the Department of Biostatistics (Dr McClelland), University of Washington, Seattle, WA; the Department of Radiology and Imaging Sciences (Drs Turkbey and Bluemke), National Institutes of Health/Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD; the Department of Internal Medicine (Dr Hundley), Wake Forest University School of Medicine, Winston-Salem, NC; the Department of Medicine (Dr Barr), Columbia University College of Physicians and Surgeons, New York, NY; the Department of Medicine (Dr Kizer), Weill Cornell Medical College, New York, NY; and the Penn Cardiovascular Institute, Department of Medicine, and Center for Clinical Epidemiology and Biostatistics (Dr Kawut), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Correspondence to: Steven M. Kawut, MD, FCCP, Perelman School of Medicine, University of Pennsylvania, 718 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104; e-mail: kawut@upenn.edu


Funding/Support: This work was supported by National Institutes of Health [Grants R01-HL086719, R01-HL077612, and N01-HC95159 through N01-HC95169].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2012 American College of Chest Physicians


Chest. 2012;141(2):388-395. doi:10.1378/chest.11-0172
Text Size: A A A
Published online

Background:  The relationship between obesity and right ventricular (RV) morphology is not well studied. We aimed to determine the association between obesity and RV structure and function in a large multiethnic population-based cohort.

Methods:  The MESA-Right Ventricle Study measured RV mass and volumes by cardiac MRI in participants aged 45 to 84 years without clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis (MESA). Participants were divided into three categories based on BMI: lean ( ≤ 24.9 kg/m2), overweight (25-29.9 kg/m2), and obese ( ≥ 30 kg/m2).

Results:  The study sample included 4,127 participants. After adjustment for demographics, height, education, and cardiovascular risk factors, overweight and obese participants had greater RV mass (6% and 9% greater, respectively), larger RV end-diastolic volume (8% and 18% greater, respectively), larger RV stroke volume (7% and 16% greater, respectively), and lower RV ejection fraction ( ≥ 1% lower) than lean participants (all P < .001). These findings persisted after adjusting for the respective left ventricular (LV) parameters.

Conclusions:  Overweight and obesity were independently associated with differences in RV morphology even after adjustment for the respective LV measure. This association could be explained by increased RV afterload, increased blood volume, hormonal effects, or direct obesity-related myocardial effects.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543