0
Editorials |

The Importance of Sex in Pulmonary HypertensionSpread the Word About the Journal in 2012

Stuart Rich, MD, FCCP
Author and Funding Information

From the Section of Cardiology, University of Chicago.

Correspondence to: Stuart Rich, MD, FCCP, University of Chicago, Section of Cardiology, 5841 S Maryland Ave, Ste L 08, MC 5403, Chicago, IL 60637; e-mail: srich@medicine.bsd.uchicago.edu


Financial/nonfinancial disclosures: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2012 American College of Chest Physicians


Chest. 2012;141(1):4-5. doi:10.1378/chest.11-2225
Text Size: A A A
Published online

Extract

The current issue of CHEST (see page 20) contains a thought-provoking article by Gabler and colleagues1 entitled, “Race and Sex Differences in Response to Endothelin Receptor Antagonists for Pulmonary Arterial Hypertension.” Gabler and colleagues1 make an important observation regarding sex differences that has widespread implications in the treatment of pulmonary arterial hypertension (PAH). They report a pooled analysis of patient-level data from six randomized placebo-controlled trials of endothelin receptor antagonists (ERAs) that looked for heterogeneity in the treatment response. All of these drugs are approved as treatments for PAH, without any specific recommendations related to their efficacy in subgroups of patients. Yet, the findings suggest that sex, and possibly race, may influence the response to ERA treatment of PAH. Specifically, women not only had a significantly greater response in terms of change in 6-min walk distance (6MWD) than did men, but women also experienced deteriorations in 6MWD when assigned to placebo, whereas men did not. This raises several important questions related to PAH and its treatment. Is the underlying pathobiology of PAH different in men vs women? Are these drugs metabolized differently in men vs women, which would account for the findings? Are the efficacies of other drugs for PAH also different in men vs women?

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543