Various plants contain anticholinergic alkaloids such as hyoscyamine and atropine. Such plants include jimsonweed, angel’s trumpet, deadly nightshade, mandrake, and black henbane.3-10 Anticholinergic symptoms generally begin within 1 h of ingestion and may continue for days. Severe toxicity results in agitation, hallucinations, hyperthermia, tachycardia, rhabdomyolysis, renal failure, and death.4,11-13 Without aggressive supportive care, death can result from rhabdomyolysis-induced renal failure, disseminated intravascular coagulation, dysrhythmias, or uncontrolled seizures. Sedation with benzodiazepines may be required to control hyperthermia and rhabdomyolysis. In the absence of contraindications (eg, history of seizures or the presence of intraventricular conduction delay, bronchospasm, or impaired atrioventricular nodal conduction), physostigmine can be used. It should be noted that duration of the anticholinergic effects can outlast the effects of the physostigmine, making redosing occasionally necessary.