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Original Research: OBSTRUCTIVE LUNG DISEASES |

Factors Associated With Bronchiectasis in Patients With COPDBronchiectasis in Patients With COPD

Miguel Ángel Martínez-García, MD; Juan José Soler-Cataluña, MD; Yolanda Donat Sanz, MD; Pablo Catalán Serra, MD; Marcos Agramunt Lerma, MD; Javier Ballestín Vicente, MD; Miguel Perpiñá-Tordera, MD
Author and Funding Information

From the Pneumology Unit (Drs Martínez-García, Soler-Cataluña, and Catalán Serra), the Service of Internal Medicine (Dr Donat Sanz), and the Radiology Department (Drs Agramunt Lerma and Ballestín Vicente), Requena General Hospital; the Service of Pneumology (Dr Perpiñá-Tordera), La Fe University Hospital; and CIBER de enfermedades respiratorias (Dr Martínez-García), Valencia, Spain.

Correspondence to: Miguel Ángel Martínez-García, MD, Unidad de Neumología, Hospital General de Requena, Paraje Casa Blanca s/n, 43230 – Valencia, Spain. E-mail: miangel@comv.es


For editorial comment see page 1107

Funding/Support: This work was supported in part by a public grant from the Sociedad Valenciana de Neumología.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;140(5):1130-1137. doi:10.1378/chest.10-1758
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Background:  Previous studies have shown a high prevalence of bronchiectasis in patients with moderate to severe COPD. However, the factors associated with bronchiectasis remain unknown in these patients. The objective of this study is to identify the factors associated with bronchiectasis in patients with moderate to severe COPD.

Methods:  Consecutive patients with moderate (50% < FEV1 ≤ 70%) or severe (FEV1 ≤ 50%) COPD were included prospectively. All subjects filled out a clinical questionnaire, including information about exacerbations. Peripheral blood samples were obtained, and lung function tests were performed in all patients. Sputum samples were provided for monthly microbiologic analysis for 6 months. All the tests were performed in a stable phase for at least 6 weeks. High-resolution CT scans of the chest were used to diagnose bronchiectasis.

Results:  Ninety-two patients, 51 with severe COPD, were included. Bronchiectasis was present in 53 patients (57.6%). The variables independently associated with the presence of bronchiectasis were severe airflow obstruction (OR, 3.87; 95% CI, 1.38-10.5; P = .001), isolation of a potentially pathogenic microorganism (PPM) (OR, 3.59; 95% CI, 1.3-9.9; P = .014), and at least one hospital admission due to COPD exacerbations in the previous year (OR, 3.07; 95% CI, 1.07-8.77; P = .037).

Conclusion:  We found an elevated prevalence of bronchiectasis in patients with moderate to severe COPD, and this was associated with severe airflow obstruction, isolation of a PPM from sputum, and at least one hospital admission for exacerbations in the previous year.

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