A history of an antecedent stressful event, emotional or physical, has been described in the majority of patients with TTC,1,3,4 even when the specific mechanisms relating the stressful event to the left ventricular dysfunction are far from fully elucidated. Different stressful trigger events were identified in our study population, such as confrontations and arguments with friends, relatives, or neighbors; unexpected death of a close relative; receipt of a negative medical diagnosis; fear of invasive medical procedures; devastating financial losses; and burglary. Given the limited data available, we are not able to exclude the possibility of a seasonal variability of the susceptibility of predisposed patients to TTC development (ie, when the patients are subjected to proper stressful trigger events). However, TTC onset time frequently depends on a stressful trigger event occurrence that cannot be anticipated or predicted because, unfortunately, it occurs randomly. Different patterns of trigger event occurrence times between the different enrolled study populations may at least in part explain the reason why a pattern of summer occurance of TTC onset was not confirmed in our cohort.