A 69-year-old woman presented with acute symptoms of fever, chills, nausea, vomiting, diarrhea, and dizziness over the previous 4 h. The patient was febrile, tachycardic, and hypotensive. Aggressive treatment of septic shock was initiated with fluid resuscitation, vasopressors, and broad-spectrum antibiotics. The patient’s medical history included diabetes, hypertension, hyperlipidemia, asthma, gastroesophageal reflux disease, and peripheral neuropathy. Her home medications include irbesartan, atorvastatin, quinine, omeprazole, primidone, and desloratadine. A review of her hospital records revealed the patient had three similar presentations over the previous 2 years.