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Abstract: Slide Presentations |

SHORT- AND LONG-TERM FUNCTIONAL STATUS OUTCOMES OF CONTINUOUS POSITIVE AIRWAY PRESSURE TREATMENT IN OBSTRUCTIVE SLEEP APNEA FREE TO VIEW

Teresita Celest S. Fuentes, MD*; Aileen G. Banzon, MD
Author and Funding Information

Philippine Heart Center, Quezon City, Philippines


Chest


Chest. 2009;136(4_MeetingAbstracts):23S-g-24S. doi:10.1378/chest.136.4_MeetingAbstracts.23S-g
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Abstract

PURPOSE:  Continuous positive airway pressure has become the standard treatment for OSA. Several studies have focused on short term clinical end points; it is not known whether the early benefits of CPAP therapy are maintained over a longer period of time. The aims of this study were to determine the short and long-term impact of CPAP treatment among moderate-severe OSA patients in improving sleepiness-related functional impairment.

METHODS:  Patients with AHI > 15 who received CPAP therapy for at least 2 months were included. The ESS and FOSQ were measured at baseline and at 2, 4 and 6 months of follow-up. The primary outcome measure was the change in ESS and FOSQ scores.

RESULTS:  Forty two patients were included in the study (35 were male, and 7 were female). The average ages of the patients were 49.5 ± 7.8 years old (range 39–64). Majority of patients were obese with an average BMI of 32.01 ± 4.8 kgm2. The changes in ESS and FOSQ evaluated through the Analysis of Variance (ANOVA) showed that there was a decrease in ESS and FOSQ from baseline up to 6 months with a p value of <0.0001. The mean difference in ESS and FOSQ scores was a large 5.0 and 5.7 points respectively. The largest mean difference in ESS and FOSQ was between scores at baseline and at 2 months with a mean difference of 3.5 (p value <0.0001, 95% CI of 1.79–5.21) and 3.27 (p <0.0001, 95% CI of −4.01 to −2.47) respectively. FOSQ showed significant differences in all domains.

CONCLUSION:  Our study provides strong evidence that the use of CPAP among moderate to severe OSA patients resulted in short and long term improvements in sleepiness-related functional impairments.

CLINICAL IMPLICATIONS:  Rapid and sustained improvements in daytime sleepiness and functional outcomes among moderate to severe OSA patients can be achieved through CPAP therapy.

DISCLOSURE:  Teresita Celest Fuentes, No Financial Disclosure Information; No Product/Research Disclosure Information

Monday, November 2, 2009

2:30 PM - 3:30 PM


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