Continuous positive airway pressure has become the standard treatment for OSA. Several studies have focused on short term clinical end points; it is not known whether the early benefits of CPAP therapy are maintained over a longer period of time. The aims of this study were to determine the short and long-term impact of CPAP treatment among moderate-severe OSA patients in improving sleepiness-related functional impairment.
Patients with AHI > 15 who received CPAP therapy for at least 2 months were included. The ESS and FOSQ were measured at baseline and at 2, 4 and 6 months of follow-up. The primary outcome measure was the change in ESS and FOSQ scores.
Forty two patients were included in the study (35 were male, and 7 were female). The average ages of the patients were 49.5 ± 7.8 years old (range 39–64). Majority of patients were obese with an average BMI of 32.01 ± 4.8 kgm2. The changes in ESS and FOSQ evaluated through the Analysis of Variance (ANOVA) showed that there was a decrease in ESS and FOSQ from baseline up to 6 months with a p value of <0.0001. The mean difference in ESS and FOSQ scores was a large 5.0 and 5.7 points respectively. The largest mean difference in ESS and FOSQ was between scores at baseline and at 2 months with a mean difference of 3.5 (p value <0.0001, 95% CI of 1.79–5.21) and 3.27 (p <0.0001, 95% CI of −4.01 to −2.47) respectively. FOSQ showed significant differences in all domains.
Our study provides strong evidence that the use of CPAP among moderate to severe OSA patients resulted in short and long term improvements in sleepiness-related functional impairments.
Rapid and sustained improvements in daytime sleepiness and functional outcomes among moderate to severe OSA patients can be achieved through CPAP therapy.
Teresita Celest Fuentes, No Financial Disclosure Information; No Product/Research Disclosure Information