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Abstract: Slide Presentations |

TRIMETHOPRIM-SULFAMETHOXAZOLE RESISTANCE IS ASSOCIATED WITH INCREASED MORTALITY IN PATIENTS WITH METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTION FREE TO VIEW

Amy J. Pate, MD*; Veera S. Mokkarala, MD; N Patel; John Vernaleo, MD; Akella Chendrasekhar, MD
Author and Funding Information

Wyckoff Heights Medical Center, Brooklyn, NY


Chest


Chest. 2009;136(4_MeetingAbstracts):11S. doi:10.1378/chest.136.4_MeetingAbstracts.11S-g
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Abstract

PURPOSE:  The prevalence of both community-acquired and hospital-acquired methicillin-resistant Staphylococcus Aureus (MRSA) has been dramatically increasing around the world. MRSA infection is known to have a high mortality rate yet there are few studies assessing predictors of mortality in these patients.

METHODS:  We conducted a retrospective chart-review in a 350-bed community-hospital in Brooklyn, New York. Based on a microbiologic database, we found 126 patients with either community-acquired or hospital-acquired MRSA. Infections that developed <48 hours after admission or were present on admission were defined as community-acquired. Infections that developed >48 hours after admission were deemed hospital-acquired. We evaluated various factors (such as age, gender, ethnicity, site of infection, etc.) potentially predictive of mortality including trimethoprim/sulfamethoxazole (TMP/SMX) sensitivity.

RESULTS:  Overall, 108 (85.72%) of 126 patients survived; 33 patients had hospital-acquired MRSA and 96 had community-acquired MRSA. We found that patients with TMP/SMX-resistant MRSA were more likely to expire than patients with TMP/SMX-susceptible MRSA (p<0.05).

CONCLUSION:  Predictors of mortality would be useful to better define and delineate patients with MRSA infections. We found that trimethoprim/sulfamethoxazole resistance is associated with increased mortality in patients with MRSA infections. Hospital-acquired MRSA had a higher mortality rate than community-acquired MRSA.

CLINICAL IMPLICATIONS:  The presence of trimethoprin/sulfamethoxazole resistance may need to be monitored so that a more aggressive approach to treatment may be rendered in patients with methicillin-resistant Staphylococcus Aureus infections.

DISCLOSURE:  Amy Pate, No Financial Disclosure Information; No Product/Research Disclosure Information

Monday, November 2, 2009

10:30 AM - 12:00 PM


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