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PREVALENCE OF IN-HOSPITAL COMPLICATIONS IN 500 PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION TREATED WITH HEPARIN 5000 IU ADMINISTERED SYSTEMICALLY VERSUS IN 500 AGE-MATCHED AND SEX-MATCHED PATIENTS TREATED WITH HEPARIN 70 IU/KG ADMINISTERED SYST FREE TO VIEW

Tarunjit Singh, MD*; Wilbert S. Aronow, MD; Kumar Kalapatapu, MD; John Shao, MD; Rasham Sandhu, MD; Anthony L. Pucillo, MD; Melvin B. Weiss, MD; Carmine Sorbera, MD; Craig E. Monsen, MD
Author and Funding Information

New York Medical College, Valhalla, NY


Chest


Chest. 2009;136(4_MeetingAbstracts):7S-i-8S. doi:10.1378/chest.136.4_MeetingAbstracts.7S-i
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Abstract

PURPOSE:  We investigated the prevalence of in-hospital complications in patients undergoing percutaneous coronary intervention (PCI) treated with heparin 5000 IU administered systemically at the time of PCI versus in age-matched and sex-matched patients undergoing PCI treated with heparin 70 IU/kg administered systemically at the time of PCI.

METHODS:  We investigated the prevalence of in-hospital complications in 500 patients undergoing PCI treated with heparin 5000 IU administered systemically (group 1) at the time of PCI versus in 500 age-matched and sex-matched patients undergoing PCI treated with heparin 70 IU/kg administered systemically (group 2) at the time of PCI. There was no significant difference in baseline characteristics, indications for PCI, cardiovascular drug therapy at the time of PCI, and prevalence of 1-vessel, 2-vessel, and 3-vessel obstructive coronary artery disease between the 2 groups.

RESULTS:  In-hospital death occurred in 0.2% of group 1 patients versus 0.8% of group 2 patients. Non-ST-segment myocardial infarction occurred in 0.2% of group 1 patients versus 0.4% of group 2 patients. Stroke occurred in 0.2% of group 1 patients versus 0.2% of group 2 patients. Stent thrombosis occurred in 0.2% of group 1 patients versus 0.8% of group 2 patients. Occlusion of a side branch occurred in 0.2% of group 1 patients versus 0.4% of group 2 patients. A hematoma needing intervention occurred in 0.2% of group 1 patients versus 0.2% of group 2 patients. Regression analysis showed that none of the differences between the 2 groups were significant.

CONCLUSION:  The sample size was adequate to conclude that a fixed low dose of heparin 5000 IU administered systemically at the time of PCI is non-inferior to standard therapy with heparin.

CLINICAL IMPLICATIONS:  A fixed low dose of heparin 5000 IU administered systemically at the time of PCI is non-inferior to standard therapy with heparin.

DISCLOSURE:  Tarunjit Singh, No Financial Disclosure Information; No Product/Research Disclosure Information

Monday, November 2, 2009

10:30 AM - 12:00 PM


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