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Abstract: Poster Presentations |

WHICH FINDINGS MAY PREDICT RESECTABILITY OF THE PATIENTS WITH LUNG CANCER? FREE TO VIEW

Miloslav Marel, MD*; Frantisek Krejbich, MD; Irena Spasova, MD; Pavla Stranska, MD; Otakar Mericka, MD; Jiri Homolka, MD; Milada Zemanova, MD
Author and Funding Information

1st Pulmonary Department, 1st Medical Faculty of the Charles University, Prague, Czech Republic


Chest


Chest. 2009;136(4_MeetingAbstracts):140S. doi:10.1378/chest.136.4_MeetingAbstracts.140S-b
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Abstract

PURPOSE:  The resectability of lung cancer (LC) is about 12% in the Czech Republic. The purpose of our study was to look for correlation between resectability and data of the patients (pts) case history and the results of examination.

METHODS:  A prospective study on 429 consecutive LC pts from the 2004–2008. Statistical evaluation was done by Chi square, in case of small numbers with Yates correction.

RESULTS:  The frequency of symptoms in time of diagnosis: cough 69%, dyspnoe 54%, loss of weight 49%, expectoration 38%, chest pain 36%, hemoptysis 17.7%, fever 16%. 80% of the set were morphologically verified, most frequent types were adenocarcinoma (24%) followed by squamous type (22,8%). 34,5% were diagnosed in stage I-IIIA. 75 pts underwent surgical therapy (17,5%). Positive predictive value for resection rate were: asymptomatic tumors (p = 0.002), low value of sedimentation rate (p = 0.0001), low value of C-reactive protein (p = 0.0003), higher value of PaO2 (p = 0.0007), peripheral tumor types on chest radiography (p = 0.037), normal bronchological findings (p = 0.00001), histological type of adenocarcinoma (p = 0.0009). Negative predictive value for resection rate were: weight loss more then 5% (p = 0.0002) and presentation of dyspnoe in time of diagnosis (p = 0.00001). No correlation with surgery: presence of hemoptysis (p = 0.894), chest pain (p = 0.16), expectoration (p = 0.4476), fever (p = 0.44), smoking habits (p = 0.12), value of PaCO2 (p = 0.314) and length of time interval between the onset of symptoms and diagnosis (p = 0.89).

CONCLUSION:  Asymptomatic tumors, low value of sedimentation rate, low value of C-reactive protein, higher value of PaO2, peripheral tumor types, normal bronchological findings and histological type of adenocarcinoma had positive predictive value for resection rate. Weight loss and presentation of dyspnoe had negative predictive value for resection rate. Presence of hemoptysis, chest pain, expectoration, fever, smoking habits, value of PaCO2 and length of time interval between the onset of symptoms and diagnosis had no correlation with surgery.

CLINICAL IMPLICATIONS:  Besides well known criteria for LC surgical treatment there are other data in the case history and results of examination which may or may not predict the resectability of LC.

DISCLOSURE:  Miloslav Marel, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, November 4, 2009

12:45 PM - 2:00 PM


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