Sarcoidosis is a complex multiorgan disease with multiple non-specific symptoms. Fatigue is an integral part of the clinical picture of sarcoidosisA considerable number of sarcoidosis patients were diagnosed with depression a major symptom of which is fatigue.The aim is to establish the correlation between fatigue and depression in patients with different clinical forms of sarcoidosis.
In this study we used two standardized questionnaires: Fatigue Assessment Scale (FAS) and Center for Epidemiologic Studies-Depression Scale –(CES-D).FAS: is 10 items fatigue questionnaire: five questions reflecting physical fatigue and five questions for mental fatigue. The response scale is a 5- point scale (1- never to 5-always). Total FAS score > 22 indicates fatigue. The full CES-D is a 20 item self –report scale designed to measure the presence and degree of depression symptomatology. Score ranges from 1- seldom or never to 4- (almost) always. Total score > 16 signifies depression.139 biopsy positive sarcoidosis patients were analyzed. Clinical characteristics of the analyzed patients with Total FAS scores and CES-D scores are presented on the Table.
Patients with extrapulmonary and patients with chronic form of sarcoidosis show significantly higher FAS scores (p < 0, 05). Statistically significant depression was present in all groups of the analyzed patients considering gender, clinical form of the disease and different organs involvement i.e:pulmonary versus extra pulmonary sarcoidosis. (p < 0,05 for the Independent samples test within groups).
Statistically significant positive correlation between the sensation of fatigue and depression was noticed (Pearson's correlation between groups P = 0.004).
Depression is an integral part of sarcoidosis. It often co - exists with fatigue.Fatigue and depression are frequently present in patients with sarcoidosis. The chronic course of disease followed by fatigue and depression may cause different problems in this category of patients.
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