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Abstract: Poster Presentations |

CORRELATION OF BODY MASS INDEX (BMI) WITH THE DIFFUSING CAPACITY (DLCO) AND THE DIFFUSING CAPACITY ADJUSTED FOR ALVEOLAR VOLUME (DLCO/VA) IN OVERWEIGHT ADULTS: A RETROSPECTIVE ANALYSIS FREE TO VIEW

Mehjabin Zahir, MD*; Prashant Sharma, MD; Kennedy Eneh, MD; Setu Patolia, MD; Rakesh Vadde, MD; Marie F. Schmidt, MD
Author and Funding Information

Interfaith Medical Center, Brooklyn, NY


Chest


Chest. 2009;136(4_MeetingAbstracts):120S-c-121S. doi:10.1378/chest.136.4_MeetingAbstracts.120S-c
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Abstract

PURPOSE:  The effect of obesity on respiratory mechanics and physiology is well recognized. However, the accurate assessment of diffusion across the membrane is a debated issue in overweight adults. Studies have shown conflicting data whether to use DLCO or DLCO/VA for an accurate measure in order to assess the gas transfer in such patient population. We have conducted a retrospective analysis on overweight adults to correlate Body Mass Index (BMI) with the Diffusion Capacity (DLCO) and Diffusion Capacity adjusted for lung volume (DLCO/VA).

METHODS:  In our study we retrospectively reviewed the pulmonary function test data of overweight adults who had a BMI of > 25. Data on FEV1/FVC, TLC, DLCO and DLCO/VA were collected and analyzed by using the SPSS 15.0 software.

RESULTS:  A total of 447 patients met the inclusion criteria and the PFT data were analyzed. 77% patients had FEV1/FVC < 80% of predicted and 48% patients had Total Lung Capacity (TLC) of < 80% of predicted. There was no correlation between BMI and DLCO by using Pearson Correlation (correlation coefficient 0.071 with p value 0.66). DLCO/VA correlated poorly with BMI (correlation coefficient 0.243 with p value 0.0). The FEV1/FVC and TLC data did not have any effect in the model.

CONCLUSION:  In our study DLCO did not correlate with BMI in overweight adults. DLCO/VA positively correlated with BMI although the correlation was poor. Further studies need to be conducted in this aspect before reaching a common consensus to consider DLCO/VA to be used for an accurate assessment of diffusion capacity in overweight adults.

CLINICAL IMPLICATIONS:  DLCO/ VA may be more accurate than DLCO in assessment of gas transfer in overweight adults but further studies need to be conducted to support this statement.

DISCLOSURE:  Mehjabin Zahir, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, November 4, 2009

12:45 PM - 2:00 PM


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