Brain natriuretic peptide (BNP) has been shown to be elevated in patients with COPD. It is unknown whether there are higher plasma levels of BNP relating to the severity of acute COPD exacerbation. This study was performed in order to compare the levels of BNP and how they relate to the severity of acute exacerbation of COPD, namely in patients requiring mechanical ventilation vs. patients not requiring ventilatory support.
A retrospective analysis of 268 patients with acute exacerbation of COPD (according to admitting diagnosis) was done checking for the primary variable of BNP level. 59 of the 268 patients required ventilatory support, while the other 209 did not. 178 out of the 268 patients had BNP levels checked on admission. Secondary variables that were documented were hemoglobin, hematocrit, PCO2, and length of stay.
The mean BNP level in the intubated patients was 432.9; while in the non-intubated patients was 370.2. When compared using the Mann Whitney test, the p value was 0.3173 suggesting that the difference was not significant. Using a ROC curve for the BNP values of both groups showed a p value of 0.3165, thus confirming that there is no significant difference between the two groups. All secondary variables had statistically significant difference between the groups.
While the BNP level was elevated in both groups with COPD exacerbation, it was not related to the severity determined by the need for mechanical ventilation. Hemoglobin, PCO2, and length of stay were all higher in the group requiring mechanical ventilation.
BNP levels in patients with COPD do not correlate with the severity of exacerbation.
Tarek Refaie, No Financial Disclosure Information; No Product/Research Disclosure Information