The goal of this study is to investigate the value and correlation of ANP serum levels to the severity of right ventricular hypertrophy and/or failure in patients (pts) with chronic lung disease and normal individuals.
35 pts with cor pulmonale and 14 controls underwent: 1)Measurement of ANP serum levels 2)Echocardiographic study 3)Spirometry and arterial blood gasses measurement.
The results showed:1)Increased ANP serum levels in 59% of pts, statistically correlated to ECHO signs of right ventricular hypertrophy. No correlation was found to lung function tests.2)ASH in 56% of pts, statistically correlated to ECHO signs of right ventricular hypertrophy and/or dilation, increase in arterial PCO2 and decrease in the FEV1 value.3)ANP serum level is not statistically correlated to ASH.
We conclude that: 1) ANP serum level could be a reliable index of right ventricular hypertrophy and/or failure in chronic lung disease. 2) Furthermore, ASH could be an important but independent factor for the prognostic severity of cor pulmonale, as well as a reliable marker of possibly developing a coincident left ventricular dysfunction, due to ASH and right ventricular volume overload, leading to paradoxical septal motion.
Consequently, further investigation is needed to clarify the possible risk of sudden cardiac death in pts with cor pulmonale and coincident ASH, as well as increased serum levels of ANP.
Ioannis Angomachalelis, No Financial Disclosure Information; No Product/Research Disclosure Information