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Abstract: Poster Presentations |

ATRIAL NATRIURETIC PEPTIDE (ANP) AND ASYMMETRIC SEPTAL HYPERTROPHY (ASH) IN CHRONIC LUNG DISEASE FREE TO VIEW

Ioannis Angomachalelis, MD*; Drosos Tsavlis, MD; Alexandros Hourzamanis, DSc; Hercules Titopoulos, DSc; Odysseas Kyriazis, MD; Demosthenes Bouros, DSc; Nestor Angomachalelis, DSc
Author and Funding Information

Department of Clinical Pulmonology, Heart-Lung Section, Aristotle University of, Thessaloniki, Greece


Chest


Chest. 2009;136(4_MeetingAbstracts):118S. doi:10.1378/chest.136.4_MeetingAbstracts.118S
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Abstract

PURPOSE:  The goal of this study is to investigate the value and correlation of ANP serum levels to the severity of right ventricular hypertrophy and/or failure in patients (pts) with chronic lung disease and normal individuals.

METHODS:  35 pts with cor pulmonale and 14 controls underwent: 1)Measurement of ANP serum levels 2)Echocardiographic study 3)Spirometry and arterial blood gasses measurement.

RESULTS:  The results showed:1)Increased ANP serum levels in 59% of pts, statistically correlated to ECHO signs of right ventricular hypertrophy. No correlation was found to lung function tests.2)ASH in 56% of pts, statistically correlated to ECHO signs of right ventricular hypertrophy and/or dilation, increase in arterial PCO2 and decrease in the FEV1 value.3)ANP serum level is not statistically correlated to ASH.

CONCLUSION:  We conclude that: 1) ANP serum level could be a reliable index of right ventricular hypertrophy and/or failure in chronic lung disease. 2) Furthermore, ASH could be an important but independent factor for the prognostic severity of cor pulmonale, as well as a reliable marker of possibly developing a coincident left ventricular dysfunction, due to ASH and right ventricular volume overload, leading to paradoxical septal motion.

CLINICAL IMPLICATIONS:  Consequently, further investigation is needed to clarify the possible risk of sudden cardiac death in pts with cor pulmonale and coincident ASH, as well as increased serum levels of ANP.

DISCLOSURE:  Ioannis Angomachalelis, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, November 4, 2009

12:45 PM - 2:00 PM


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