Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a promising method in the mediastinal staging of non-small cell lung cancer (NSCLC). However, the role of EBUS-TBNA in the diagnosis of lung cancer has not been well studied.
We retrospectively reviewed 126 patients who underwent EBUS-TBNA in order to diagnose radiologically suspected lung cancer from June, 2006 to February, 2009. The patients had EBUS-TBNA accessible masses or lymph nodes that were highly suspicious for malignancy.
EBUS-TBNA was performed on 195 lesions (126 mediastinal nodes, 24 hilar nodes, 44 lung masses & 1 mediastinal mass) in 126 patients without complications. EBUS-TBNA confirmed 110 malignant cases (91 NSCLC, 15 small cell lung cancer, 3 metastatic lung cancer & 1 lymphoma) and 6 benign cases (1 adenoma, 3 tuberculosis, 1 sarcoidosis & 1 aspregillosis). The overall diagnostic yield of EBUS-TBNA was 92.1% (116/126). Nine of the 10 cases that were not confirmed to be malignant or to have specific benign disease by EBUS-TBNA were diagnosed by other methods (2 NSCLC, 1 Castleman's disease, 1 lymphoma, 1 hamartoma, 1 tuberculosis & 3 pneumonia). One case not confirmed by any diagnostic method was considered to be false negative. The sensitivity and diagnostic accuracy of EBUS-TBNA in the diagnosis of malignancy were 95.7% (110/115) and 96.0% (121/126), respectively. Those values in the diagnosis of lung cancer were 97.2% (106/109) and 97.6% (123/126), respectively.
EBUS-TBNA showed high diagnostic values in the diagnosis of lung cancer when EBUS-TBNA accessible masses or lymph nodes that were highly suspicious for malignancy were noted. EBUS-TBNA is recommendable for these patients.
The role of EBUS-TBNA in the diagnosis of lung cancer.
Jeong Eun Lee, No Financial Disclosure Information; No Product/Research Disclosure Information