To investigate the prevalence of acute myocardial infarction (AMI) in patients hospitalized for thrombotic thrombocytopenic purpura (TTP).
Thirty-eight patients (27 women and 11 men), mean age 44 years, were hospitalized with the diagnosis of TTP confirmed by a hematologist. We investigated the incidence of AMI which developed during hospitalization for TTP. AMI was diagnosed by new ECG changes, increased serum cardiac troponin I levels, and clinical symptomatology.
Of the 38 patients, 8 (21%) developed new Q-wave AMI. Of these 8 patients with new AMI, 2 (25%) developed atrial fibrillation, 1 (13%) developed atrial flutter, and 1 (13%) developed supraventricular tachycardia.
In conclusion, new Q-wave AMI developed in 21% of 38 patients hospitalized with a diagnosis of TTP. Supraventricular tachyarrhythmias developed in 50% of patients with TTP who developed AMI.
Patients hospitalized for TTP have a high incidence of new AMI accompanied by supraventricular tachyarrhythmias and should be monitored for this.
Kaushang Gandhi, No Financial Disclosure Information; No Product/Research Disclosure Information