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Abstract: Poster Presentations |

THERAPY OF PATIENTS HOSPITALIZED FOR HEART FAILURE WITH ABNORMAL VERSUS NORMAL LEFT VENTRICULAR EJECTION FRACTION FREE TO VIEW

Sachin Sule, MD*; Wilbert S. Aronow, MD
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New York Medical College, Valhalla, NY


Chest


Chest. 2009;136(4_MeetingAbstracts):106S. doi:10.1378/chest.136.4_MeetingAbstracts.106S-a
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Abstract

PURPOSE:  To investigate treatment of patients hospitalized for heart failure (HF) with abnormal versus normal left ventricular ejection fraction (LVEF).

METHODS:  We investigated treatment of 200 consecutive patients hospitalized for HF. Of 200 patients, 100 (50%) had abnormal echocardiographic LVEF ( < 50%), and 100 (50%) had normal LVEF.

RESULTS:  All 200 patients were treated with diuretics and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Beta blockers were used in 97% of patients with abnormal LVEF versus 100% with normal LVEF, p not significant (NS). Digoxin was used in 27% of patients with abnormal LVEF versus 0% with normal LVEF (p < 0.001). Nitrates were used in 52% of patients with abnormal LVEF versus 26% with normal LVEF (p < 0.001). Hydralazine was used in in 6% of patients with abnormal LVEF versus 0% with normal LVEF (p < 0.02). Diltiazem was used in 0% of patients with abnormal LVEF versus 10% with normal LVEF (p < 0.005). Inotropes were used in 4% of patients with abnormal LVEF versus with normal LVEF (p < 0.05). A cardioverter-defibrillator was used in 36% of patients with abnormal LVEF versus 0% with normal LVEF (p < 0.001). Cardiac resynchronization therapy was used in 12% of patients with abnormal LVEF versus 0% with normal LVEF (p < 0.001). In-hospital mortality was 7% in patients with abnormal LVEF versus 1% of patients with normal LVEF (p < 0.05). Mean duration of hospitalization was 7 days in patients with abnormal LVEF versus 7 days in patients with normal LVEF (p NS). Mean New York Heart Association (NYHA) class at hospital discharge was 2.56 in patients with abnormal LVEF versus 2.52 in patients with normal LVEF (p NS).

CONCLUSION:  After optimal medical therapy for HF, in-hospital mortality was higher and duration of hospitalization and NYHA class at discharge were similar in patients with abnormal LVEF versus patients with normal LVEF.

CLINICAL IMPLICATIONS:  After optimal medical therapy for HF, patients with abnormal LVEF have a higher in-hospital mortality and a similar duration of hospitalization and NYHA class at discharge as those with normal LVEF.

DISCLOSURE:  Sachin Sule, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, November 4, 2009

12:45 PM - 2:00 PM


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