Abstract: Poster Presentations |


Jean-Christian Borel, MSc; Pascale Roux-Lombard, MD; Renaud Tamisier, MD; Claire Arnaud, PharmD; Denis Monneret, MSc; Nathalie Arnol, MSc; Jean-Philippe Baguet, MD; Patrick Levy, MD; Jean-Louis Pepin, MD*
Author and Funding Information

INSERM ERI 17, HP2 Laboratory, Joseph Fourier University, Grenoble, France


Chest. 2009;136(4_MeetingAbstracts):104S-c-105S. doi:10.1378/chest.136.4_MeetingAbstracts.104S-c
Text Size: A A A
Published online


PURPOSE:  Obesity hypoventilation syndrome (OHS) is associated with increased cardiovascular morbidity-mortality. Little is known on what daytime moderate chronic hypoventilation adds to obesity on systemic inflammation, adipokine production and endothelial dysfunction. Aim: To compare inflammatory status and endothelial function in OHS versus “uncomplicated obese” patients (UO), matched for BMI, age and sex.

METHODS:  Diurnal blood gazes, respiratory function, CO2 ventilatory response, polysomnography and endothelial function, measured by reactive hyperemia peripheral arterial tonometry (RH-PAT), were assessed. Inflammatory (Leptin, RANTES, MCP1, IL6, IL8, TNFα, Resistin) and anti-inflammatory (adiponectin, IL1-RA) cytokines were measured by commercially available multiplex beads immunoassays.

RESULTS:  14 OHS (BMI: 41 ± 5.2 kgm-2, PaCO2: 6.5 ± 0.4 kPa, age: 57 ± 10 years) and 39 UO patients (BMI: 40.9 ± 5.1 kgm-2, PaCO2: 5.3 ± 0.4 kPa, 56 ± 10 years) were included. PaCO2 was significantly higher in OHS (p < 0.0001) whereas PaO2, vital capacity and CO2 chemoresponsiveness were lowered (p < 0.02). Serum RANTES levels were significantly increased in OHS (55.9 ± 55.3 vs 23.3 ± 15.8 ng/ml p = 0.003) and correlated with daytime PaCO2 (r=0.53 p = 0.0001). Serum adiponectin was reduced in OHS (7.6 ± 2.9 vs 13.7 ± 7.8μg/ml p = 0.004). Endothelial function was more impaired in OHS (p = 0.006) compared to UO and negatively correlated with PaCO2 (r=−0.37 p = 0.009) and positively with PaO2 (r=0.36 p = 0.01).

CONCLUSION:  Compared to UO, OHS is associated with a specific increase in the proatherosclerotic RANTES chemokine, a decrease in the antinflammatory adipokine adiponectin and impaired endothelial function. These three conditions are known to be strongly associated with an increased cardiovascular risk.

CLINICAL IMPLICATIONS:  This study may explain why excess in cardiovascular morbidity is observed during OHS.

DISCLOSURE:  Jean-Louis Pepin, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, November 4, 2009

12:45 PM - 2:00 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543