Abstract: Poster Presentations |


Pao-Hsien Chu; Su-Chin Shen, MD; Wan-Jing Ho
Author and Funding Information

Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan ROC


Chest. 2009;136(4_MeetingAbstracts):103S-c-104S. doi:10.1378/chest.136.4_MeetingAbstracts.103S-c
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PURPOSE:  Glaucomatocyclitic crisis (GCC) is a syndrome of recurrent unilateral increased intraocular pressure associated with mild cyclitis and few clinical symptoms. This study assesses brachial artery endothelium-dependent flow-mediated vasodilation (FMD) as an indicator of vascular endothelial function to describe the association between GCC and endothelial dysfunction excluding age effects.

METHODS:  This prospective study was conducted from January 2007 to December 2008, comprised of 10 patients with GCC, and 12 age- and gender-matched normal controls. Detailed clinical parameters were reviewed, including high sensitive C-reactive protein (hs-CRP), homocystine, anti-SSA, anticardiolipin antibodies, and HLA type. Brachial artery FMD and endothelium-independent, nitroglycerin-mediated vasodilation (NMD) were studied by using high-resolution 2-dimensional (2-D) ultrasonic imaging.

RESULTS:  Ten patients with GCC were evaluated. The mean age of the patients was 37.8 years including 3 women (30%) and 7 men (70%). There were no significant difference between GCC patients and control subjects with regard to basal data, including body mass index, smoking, blood pressure, complete blood count and routine blood biochemistries. Homocystine, and hs-CRP, were within normal limits. There were 20% patients with positive of HLA-B27, anti-SSA and anticardiolipin antibodies. The nitroglycerin-mediated vasodilation in the GCC patients was not significantly different from the control group. The FMD value was much lower (4.64 ± 3.27%) in the GCC group as compared to the control groups (8.09 ± 2.56%, P < 0.001).

CONCLUSION:  The significantly lower FMD in GCC patients implies the peripheral vascular endothelial dysfunction. However, the 20% positive HLA-B27, anti-SSA and anticardiolipin antibodies are associated with GCC and abnormal FMD.

CLINICAL IMPLICATIONS:  GCC patients implies the peripheral vascular endothelial dysfunction.

DISCLOSURE:  Pao-Hsien Chu, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, November 4, 2009

12:45 PM - 2:00 PM




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