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Abstract: Poster Presentations |

EMPHYSEMA ANALYSIS BY CT SCAN DENSITOMETRY IN ALPHA-1 ANTITRYPSIN DEFICIENCY (A1ATD) PATIENTS: CORRELATION WITH LUNG FUNCTION TESTS (LFT) FREE TO VIEW

Ana Filipa C. Costa, MD*; Hugo Matos, MD; Susana Basso, MD; Yvette Martins, MD; Carlos Mendonça, MD
Author and Funding Information

Centro Hospitalar de Coimbra, EPE, Coimbra, Portugal


Chest


Chest. 2009;136(4_MeetingAbstracts):92S-b-93S. doi:10.1378/chest.136.4_MeetingAbstracts.92S-b
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Abstract

PURPOSE:  A1ATD is a genetic disease characterized by the presence of emphysema in the lungs. CT scan densitometry has emerged as the most sensitive non-invasive method for detecting and quantifying emphysema. Despite this, it has some limitations that preclude its use in follow-up. The purpose of this study was to evaluate if the extent of emphysema determined by CT scan densitometry could be assessed by LFT, which have less limitations.

METHODS:  In this prospective study, A1ATD patients underwent a CT scan to determine emphysema extent and contemporary LFT. Emphysema extent determined by CT scan and LFT parameters (FEV1, FEV1/FVC, FEF25–75%, TLC, RV, RV/TLC, FRC, DLCO, KLCO, pO2) were tested by Pearson correlation coefficient and multiple linear regression analysis.

RESULTS:  31 patients (51,6% males, age 45 ± 16,3 years) with various A1ATD phenotypes were evaluated. Emphysema extent ranged from 0% to 44,39%. Except for TLC, RV/TLC and FRC all other variables correlated significantly with emphysema extent. After performing a stepwise multiple regression analysis, FEV1/FVC, FEF25–75% and DLCO were the only variables retained. The multiple regression model explained 91,8% of the variability of emphysema extent measured by CT scan.

CONCLUSION:  In our study, the combination of FEV1/FVC, FEF25–75% and DLCO measurement provided a good estimate of the extent of emphysema as measured by CT scan in A1ATD patients.

CLINICAL IMPLICATIONS:  Although this model has to be tested in patients other than the ones from which it was generated, if it proves to be valid, it will allow a good estimate of emphysema extent for the follow up of patients with A1ATD, without exposure to radiation.

DISCLOSURE:  Ana Filipa Costa, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, November 4, 2009

12:45 PM - 2:00 PM


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