A multimodality bronchoscopy platform that incorporates several imaging techniques of varying sensitivity and specificity, resolution, and coverage area, has the potential to provide medical practitioners with improved means for assessing elements of airway wall architecture in-vivo. The purpose of this study is to describe the appearance of airway abnormalities using a multimodality platform that includes white light bronchoscopy, endobronchial ultrasound, and optical coherence tomography (OCT).
White light flexible bronchoscopy was performed through a rigid 12 mm EFER-Dumon bronchoscope (Bryan Corps, Woburn MA). Airway wall extension was then studied using real-time endobronchial ultrasound (Olympus Optical Co. Ltd., Tokyo, Japan) and optical coherence tomography was performed using a commercial compact OCT system (Niris® Imaging System, Imalux® Corp., Cleveland, USA). Cases studied include tracheopathia osteochondroplastica, endobronchial tumors, idiopathic and Wegener-related tracheal stenoses.
Results of OCT system are compared with results of white light bronchoscopy, endobronchial ultrasound and histology examination. The resolution, penetration depth, contrast, and field of view of these imaging modalities are presented(Figure).
Commercially available systems used as part of a multimodality bronchoscopy platform to study airway abnormalities have their unique capacity in terms of resolution, penetration depth, contrast, and field of view.
Multimodality bronchoscopic imaging may complement interventional bronchoscopic procedures, help select patients for open resectional or bronchoscopic surgery, help understand the pathogenesis of airway disorders and assist in airway-related research.
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