Transfusion of blood products is a known risk factor for ARDS. Previous studies performed in tertiary care institutions included referral patient populations, potentially biasing the results.
In a population-based retrospective cohort study we identified ARDS patients, age > 18yrs, residents of Olmsted County, admitted to one of the two Mayo Clinic hospitals in year 2006, excluding those who presented with ARDS on admission. In a nested case control study, ARDS patients were matched to controls by age, gender, predisposing medical condition and a lung injury prediction score. Transfusion exposures between hospital admission and onset of ARDS (in cases) and during corresponding amount of time (in controls), were compared using Wilcoxon signed rank and McNemar test, as appropriate.
Exposure to any transfusion was similar between 78 patients who developed ARDS after hospital admission and 78 controls. (42% vs.34%, p = 0.35). However, ARDS cases received significantly higher number of specific blood products, and were more likely to die in the hospital (Table 1).
This population based matched case control study confirmed the association between blood product transfusion and hospital acquired ARDS. ARDS cases had higher attributable hospital mortality.
The observed relationship between transfusion and hospital acquired ARDS, supports current efforts on prevention of transfusion-related acute lung injury.
Adil Ahmed, No Financial Disclosure Information; No Product/Research Disclosure Information