Vitamin D was used as antituberculosis treatment before the advent of antituberculosis chemotherapy. Recently, some studies found that serum vitamin D is related to susceptibility to tuberculosis. But, there is no similar study in Korea. The aim of study is to find the relationship of serum vitamin D3 level in infected patient with tuberculosis in Korea and susceptibility to tuberculosis.
Serum 25hydroxyvitamin D3 concentrations was measured in 117 patients before treatment in patients with active tuberculosis and 42 healthy controls one time. The prevalence of vitamin deficiency in patients with active tuberculosis and healthy controls was observed. We observed whether serum 25 hydroxyvitamin D concentrations is related to extrapulmonary tuberculosis, cavity, the extent of lung involvement, AFB positive results or not.
The mean serum vitamin D concentration was 47.5ng/ml(SD ± 13.7), there was no vitamin D3 deficiency and the prevalence of vitamin D3 insufficiecny was 2.1% (1/47 person) in healthy group. The mean serum vitamin D concentration was 34.02ng/ml (SD ± 21.1), the prevalence of vitamin D3 deficiency was 24.7% (19/117person), the prevalence of vitamin D3 insufficiency was 23.9% (28/117 person) in tuberculosis group.If vitamin D3 concentration below normal range in infected patient with tuberculosis is risk factor for progression to extrapulmonary tuberculosis (odds = 2.2 CI : 1.2–3.8 P:0.04). But. Although vitamin D3 concentration is below normal range in infected patient with tuberculosis, there is no association of vitamin D deficiency and clinical manifestations of tuberculosis infection in Korea - frequency of cavitation (odds = 1.7 CI:0.9–3.3 P:0.069), bilateral involvement (odds = 1.0 CI: 0.7–1.4 P:0.018).
Considering the fact that the mean 25hydroxyvitamin D3 concentration in tuberculosis group is lower than in healthy group, low serum 25hydroxyvitamin D3 concentration could be one cause of susceptibility to tuberculosis. Among tuberculosis group, serum 25hydroxyvitamin D3 concentration in extrapulmonary tuberculosis group is more lower than pulmonary tuberculosis is considered as serum vitamin D3 concentration may play a role to progress to extrapulmonary tuberculosis manifestation.
vitamin D3 plays as a means of immunologic response to tuberculosis infection in human.
Jusang Kim, No Financial Disclosure Information; No Product/Research Disclosure Information