Diabetes mellitus (DM) is a risk factor for development of tuberculosis. But the risk varies according to races and regional prevalence of tuberculosis or DM. Burden of tuberculosis in South Korea is intermediate. We tried to evaluate the influence of DM in the development of tuberculosis in Koreans.
We carried out retrospective cohort study in one secondary referral hospital. Incidence of tuberculosis for four years in diabetic cohort was compared with that in non-diabetic hypertensive cohort. Diabetics who visited our diabetic center and non-diabetic hypertensive patients who visited our cardiology department during Jan 2004 to April 2004 were assigned to diabetic cohort and non-diabetic hypertensive cohort, respectively. Patients of each cohort had to receive medications to control their diseases. Patients with end-stage renal disease, malignancy or HIV positive patients were excluded. Tuberculosis-free survival rates of each cohort was calculated using life table method and difference of these two rates was estimated using Gehan's generalized Wilcoxon statistics.
Incidences of tuberculosis for four years were 22 in diabetic cohort (n = 2539, mean age 59.2, male 44.7%) and 9 in non diabetic hypertensive cohort (n = 1907, mean age 60.0 male 43.2%). Estimated annual incidences per 100.000 persons in each cohort were 229 and 145 persons, respectively. There was no significant difference in cumulative tuberculosis-free survival rate between two cohorts (p = 0.249).
In Korean diabetics, there was a trend for higher incidence of tuberculosis than in non-diabetic hypertensive patients, but the difference of these incidences were not statistically significant.
This is first report that tried to find out the effect of DM in the development of TB in Korean diabetics. Study with larger population will elucidate the attributable risk of DM more clearly.
Byoung Hoon Lee, No Financial Disclosure Information; No Product/Research Disclosure Information