To investigate the rate of cerebro- and cardiovascular events and neuropsychological disturbances among Asian patients with obstructive sleep apnea syndrome (OSAS), who among them developed, improved or had worsened outcomes, whether they had continuous positive airway pressure (CPAP) therapy or not.
A total of 46 patients (Male:34; Female:12) with OSAS who were seen at our sleep clinic 3 years previously were followed up.The average follow up period was 2 years. Baseline interview, physical evaluation and polysomnographic recording were reviewed. At follow up, a standardized questionnaire was sent thru e-mail or patients were contacted through their phone or seen at the clinic. If possible, a repeat polysomnographic study was done.
There was improvement of Epworth Sleepiness Scale (baseline mean score: 11–15 to follow up mean score: 6–10) whether with CPAP therapy or not (p value: 0.977) Furthermore, the severity of OSA was reduced (from severe to moderate, p value: 0.137) with CPAP therapy. There was reduction in hypertension on follow up (baseline: 80.4%, ffup: 52.2%), with greater reduction in the CPAP group (p value: 0.0129). The rate of coronary artery bypass graft (mean: 3, 6.5%), cerebrovascular accident (mean:1, 2.2%) and dysrhythmia (mean: 8, 17.4%) was higher in the CPAP group, but noted to those with poor compliance.
Our findings indicate that the most common comorbidity in our subject population was hypertension found in 80% of the patients. The risk for developing hypertension, cardiovascular and cerebrovascular events is also increased. There was no statistical significance in the co morbidities except for the presence of dysrhythmia seen in the CPAP group, however this was seen in patients who are non compliant to the treatment.
This study confirms that treatment of obstructive sleep apnea among Asians with CPAP may lower the rate of cerebro- and cardiovascular risks as well as neuropsychological disturbances.
Irma Melissa Abara, No Financial Disclosure Information; No Product/Research Disclosure Information