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Abstract: Poster Presentations |

TROPONIN I CORRELATES WITH HYPOXEMIA IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA(CAP) FREE TO VIEW

Mahmoud Q. Moammar; Muhammad I. Ali, MD; Nader Mahmood, MD; Fawad A. Chaudry, MD; Tarek Refaie, MD; M. A. Khan, MD
Author and Funding Information

St Joseph's Reg. Med. Ctr, Paterson, NJ


Chest


Chest. 2009;136(4_MeetingAbstracts):52S. doi:10.1378/chest.136.4_MeetingAbstracts.52S
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Abstract

PURPOSE:  CAP is still considered the sixth most common overall cause of death. An invariant aspect of the pathophysiology of CAP is impairment of the normal pulmonary ventilation- perfusion dynamics (V/Q mismatch).Troponin I can be used as a biomarker of cardiac stress. This study evaluates the correlation between A-a gradient as a marker of hypoxemia and troponin I as a marker of cardiac stress.

METHODS:  The study site was a 750-bed urban teaching hospital. It examined a retrospective cohort of 703 hospitalized patients developed over a four-year period. Association between troponin I and A-a gradient was examined by linear and non-parametric correlation.

RESULTS:  Value of rs for troponin I was 0.68 (p value 0.0023). Regression analysis was also strongly significant p < 0.0001 with r2 = 0.48.

CONCLUSION:  Our study indicates that there is a strong correlation between troponin I and A-a gradient.

CLINICAL IMPLICATIONS:  These data suggest the possible applicability of troponin I as adjunct to other markers and indices of CAP severity.

DISCLOSURE:  Mahmoud Moammar, No Financial Disclosure Information; No Product/Research Disclosure Information

Tuesday, November 3, 2009

12:45 PM - 2:00 PM


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