CAP is still considered the sixth most common overall cause of death. An invariant aspect of the pathophysiology of CAP is impairment of the normal pulmonary ventilation- perfusion dynamics (V/Q mismatch).Troponin I can be used as a biomarker of cardiac stress. This study evaluates the correlation between A-a gradient as a marker of hypoxemia and troponin I as a marker of cardiac stress.
The study site was a 750-bed urban teaching hospital. It examined a retrospective cohort of 703 hospitalized patients developed over a four-year period. Association between troponin I and A-a gradient was examined by linear and non-parametric correlation.
Value of rs for troponin I was 0.68 (p value 0.0023). Regression analysis was also strongly significant p < 0.0001 with r2 = 0.48.
Our study indicates that there is a strong correlation between troponin I and A-a gradient.
These data suggest the possible applicability of troponin I as adjunct to other markers and indices of CAP severity.
Mahmoud Moammar, No Financial Disclosure Information; No Product/Research Disclosure Information