As more and more cases of bronchogenic carcinoma are diagnosed due to changed personal, environmental conditions and better diagnostic facilities. These patients are prone for secondary pulmonary infection. However association of aspergillosis with bronchogenic carcinoma was not defined clearly.
The present study was done in 80 patients of bronchogenic carcinoma with 20 healthy controls. All cases were subjected to fiberoptic bronchoscope for confirmation of bronchogenic carcinoma and for collection of broncho-alveolar lavage (BAL). BAL were subjected for direct fungal examination, Aspergillus PCR and galactomannan (GM) detection using a 1-stage immunoenzymatic sandwich microplate assay and blood samples were collected for fungal serology by double immunodiffusion (DID), ELISA and dot blot assay (DBA).
4patients (5%) were categorized with definite IPA based on histopathological, clinical and radiological findings. 16 patients (20%) were probable IPA and 12 patients (15%) as possible IPA, 48 patients (60%) were categorized as non IPA. Results of various methods were analysed –sensitivity of PCR and serological tests was 100% for definite IPA whereas sensitivity of PCR was higher than serological test in probable IPA.
Current study indicates there is frequently association between Bronchogenic carcinoma and Aspergillosis.
All cases of Bronchogenic carcinoma should also be evaluated for Aspergillus infection and should be treated accordingly. More studies are needed for role of Aspergillus infection in pathogenesis of Bronchogenic carcinoma.
Rakesh Bhargava, No Financial Disclosure Information; No Product/Research Disclosure Information