The chemical pleurodesis has become the preferred treatment for definitive management of malignant o benign pleural effusions. Different sclerosing agents have been utilized, like talc, tetracycline, steroids, silver nitrate, etc. A recent review of literature last 20 years, we find that there are just a few paper works about markers in the success chemical pleurodesis. The objective of this study is to present our experience in use of Reactive C Protein (RCP) as a marker of pleurodesis success.
Eighteen patients were enrolled into the study, none patients had infection. All received a chest tube (28–32 F) with local anesthesia. Samples of blood were collected before and after the days 3 and 5 of pleurodesis with 100 ml saline solution, oxitetracycline 2,5 grs, lidocaine 2 % 3 cc., and was searched for RCP. We evaluated at monthly intervals with respect to the success of pleurodesis. Pleurodesis therapy was considered to be successful if there were no recurrence of the effusion. Statistical analysis was Pair T test.
Sixteen patients were followed. Eight were female and eight were male. Fifteen patients had malignant pleural effusion and one patient had benign pleural effusion. The average of age was 64.4 years and range between 42–89 years. The serum RCP was significantly increased in the 3rd day, compared with the serum RCP before pleurodesis (p < 0.002). The serum RCP was significantly increased in the 5th day, compared with the serum reactive C protein the 3rd day (p < 0.003). Two patients died.
It is concluded that high serum RCP after chemical pleurodesis, is a good predictor of the success in pleurodesis.
Serum Reactive C Protein measure before and after chemical pleurodesis may be a marker of the success in pleurodesis.
Rodrigo Machuca, No Financial Disclosure Information; No Product/Research Disclosure Information