There is a paucity of literature in the PubMed Database regarding sleep characteristics and polysomnographic findings regarding pediatric HIV patients. The objective of this abstract is to provide some preliminary data regarding the prevalence of obstructive sleep apnea in this patient population.
Data is reviewed from 11 pediatric HIV-positive subjects enrolled in a larger clinical trial at a major medical center. Recruited subjects and their caregivers completed a modified Sleep Self-report (SSR) and a modified Children's Sleep Habits Questionnaire (CSHQ), respectively, to assess sleep behavior. The subjects then underwent overnight polysomnography (NPSG). The NPSG was scored by experienced sleep technicians and reviewed by two sleep fellows. The prevalence of OSA in this sample population is presented here.
Of the 11 HIV positive subjects, age 9–18yo, 55% were female. 36% of the PSG studies (4/11) revealed an Apnea-Hypopnea Index (AHI) > 1 event per hour (1.3–12.9). Of the four OSA patients, 50% were male.
Data suggests that children with HIV are at higher risk of developing obstructive sleep apnea syndrome. The reported prevalence of NPSG-diagnosed OSA in this population (36%) is much higher than published reports of prevalence (0.2–11%) based on various diagnositic criteria ranging from parent report to NPSG diagnosis. 1 This finding is also consistent with as yet unpublished data at another major medical center which found a 45% prevalence of OSA (AHI > 1) among its 11 pediatric HIV patients. Further larger studies need to be performed to confirm these findings and to rule out the chance of confounding due to African American race and obesity. 1. Lumeng JC and Chervin RD. Epidemiology of Pediatric Obstructive Sleep Apnea. The Proceedings of the American Thoracic Society 5:242–252 (2008).
The importance of screening for OSA may contribute to improving patient fatigue and quality of life.
Catherine Kier, No Financial Disclosure Information; No Product/Research Disclosure Information