The purpose of this report is to describe the prevalence, pulmonary function tests and imaging of patients with silicosis undergoing lung transplantation in our institution.
Medical Records of patients who underwent lung transplantation during the period from February 1990 to December 2007 were reviewed to assess the indication for lung transplantation. Pulmonary Function Tests (PFTs), X-Rays and chest CT scans pre-lung transplantation were evaluated in those patients transplanted due to silicosis.
626 patients were transplanted over 18 years at The Cleveland Clinic. Two (0.3%) patients were transplanted due to silicosis. Both patients transplanted for silicosis had a very severe obstructive pattern in PFTs with an FEV1 in a range between 0.68–1.20 liters (17–29% of the predicted value). Imaging tests showed a pattern of progressive massive fibrosis characterized by calcified mediastinal lymph nodes and calcified soft tissue masses within the lung parenchyma.
Silicosis remains an uncommon diagnosis within patients undergoing lung transplantation. In this series, the prevalence of silicosis as an indication for lung transplantation was 0.3 %. A very severe obstructive lung disease in spirometry and a progressive massive fibrosis pattern in imaging studies were common findings pre-lung transplantation.
Patients with silicosis need be followed with PFTs to determine their FEV1. Very severe obstructive lung disease is seen in patients with silicosis referred for lung transplantation.
Ariel Modrykamien, No Financial Disclosure Information; No Product/Research Disclosure Information