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Abstract: Poster Presentations |

PULMONARY FUNCTION TESTS AND IMAGING PATTERNS IN PATIENTS UNDERGOING LUNG TRANSPLANTATION FOR SILICOSIS FREE TO VIEW

Ariel M. Modrykamien, MD*; Ravindra Gudavalli, MD; Anita Reddy, MD
Author and Funding Information

Cleveland Clinic, Cleveland, OH


Chest


Chest. 2009;136(4_MeetingAbstracts):23S. doi:10.1378/chest.08-2954
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Abstract

PURPOSE:  The purpose of this report is to describe the prevalence, pulmonary function tests and imaging of patients with silicosis undergoing lung transplantation in our institution.

METHODS:  Medical Records of patients who underwent lung transplantation during the period from February 1990 to December 2007 were reviewed to assess the indication for lung transplantation. Pulmonary Function Tests (PFTs), X-Rays and chest CT scans pre-lung transplantation were evaluated in those patients transplanted due to silicosis.

RESULTS:  626 patients were transplanted over 18 years at The Cleveland Clinic. Two (0.3%) patients were transplanted due to silicosis. Both patients transplanted for silicosis had a very severe obstructive pattern in PFTs with an FEV1 in a range between 0.68–1.20 liters (17–29% of the predicted value). Imaging tests showed a pattern of progressive massive fibrosis characterized by calcified mediastinal lymph nodes and calcified soft tissue masses within the lung parenchyma.

CONCLUSION:  Silicosis remains an uncommon diagnosis within patients undergoing lung transplantation. In this series, the prevalence of silicosis as an indication for lung transplantation was 0.3 %. A very severe obstructive lung disease in spirometry and a progressive massive fibrosis pattern in imaging studies were common findings pre-lung transplantation.

CLINICAL IMPLICATIONS:  Patients with silicosis need be followed with PFTs to determine their FEV1. Very severe obstructive lung disease is seen in patients with silicosis referred for lung transplantation.

DISCLOSURE:  Ariel Modrykamien, No Financial Disclosure Information; No Product/Research Disclosure Information

Tuesday, November 3, 2009

12:45 PM - 2:00 PM


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