Analysis of the factors involved in uncontrolled bronchial asthma (BA).
Between October 2007 and November 2008 we evaluated 584 consecutive patients, known and treated for BA, and collected general data, medical history, disease onset, spirometry, treatment duration, treatment, asthma control test (ACT). The association of variables was analyzed by calculating the odds ratio (OR) together with confidence intervals (CI) in a univariate analysis. The significant independent variables were utilized to create models of multivariate logistical analysis in order to identify the most important predictors.
584 patients, 162 males (27.74%), 422 females (72.26%), medium age 45.38 ± 17.48 years (4–85), 14 % smokers, ACT <19 (36.2%), 20–24 (48.8%), 25 (15%), medium duration for control 3.93 ± 2.22 months, 78.46% patients with inhaled corticosteroids, 63.4% with normal spirometry, 52.5% with allergy, 43.1% exacerbations, 31.3% professional exposure, 4 predictors for uncontrolled BA: exacerbations OR 4.11, CI 3.30–7.48, p <0.001, professional exposure OR 2.29, CI 1.23–4.26, p = 0.009, altered lung function on spirometry OR = 1.18, CI 1.02–1.36, p = 0.021 (obstruction OR 3.78 CI 1.76–7.78, p = 0.0001), duration of disease (months) OR=1.02, CI 1.00–1.03, p = 0.021.
36, 2% of patients had uncontrolled asthma. The most important predictors for lack of control are exacerbations, professional exposure and present obstructive dysfunction.
Uncontrolled asthma is a serious problem, altering the quality of live, and consuming a lot of resources. Evaluation of the factors related to lack of control is useful.
Oana Arghir, No Financial Disclosure Information; No Product/Research Disclosure Information